First Twice-Daily Formulation Of Leukotriene Synthesis Inhibitor Provides Additional Treatment Option For Asthma Patients

ZYFLO CR® and ZYFLO® (zileuton tablets) be the merely FDA-approved leukotriene mixture inhibitors encircled by support of the prophylaxis and hardened management of asthma in adults and brood 12 years of age and elder. ZYFLO CR® and ZYFLO® are not designate for use in the reversal of bronchospasm in acute asthma attack, but can be chronic during acute exacerbations of asthma. Leukotrienes are inflammatory peacekeeping troop in asthma that can trigger asthma symptom, with inflammation, protrusion, bronchoconstriction and mucus secretion. ZYFLO CR® use SkyePharma PLC's (LSE: SKP) proprietary Geomatrix® pills transfer technology, which controls the amount and rate of drug released into the article.

"We expletive esteem our marketing partner's glory in securing FDA approval of the only twice-daily leukotriene synthesis inhibitor for asthma," said Mel Engle, President and CEO of DEY. "ZYFLO CR® have a inimitable contraption of judgment that, joint subsequent to its twice-daily dose regimen, could really enlarge and make a payment to the treatment option relieve to asthma patients. We are overjoyed to slip in cooperation together in commercializing Critical Therapeutics' ZYFLO CR®, which will hold on to maddening to expand DEY's individual near in asthma and respiratory tell." In March 2007, Critical Therapeutics and DEY enter into an agreement for the co-promotion of ZYFLO CR® and ZYFLO®, the immediate-release formulation of zileuton. DEY's mart oblige begin promote ZYFLO® antagonistic April 30, 2007. Upon the launch of ZYFLO CR®, the combined sales forces of the two company will open promoting ZYFLO CR® to almost 15,000 allergists, pulmonologists and earliest care physician across the U.S.

The recommended dose of ZYFLO CR® be two 600 mg extended-release tablets two times daytime by day, inside one hour after morning and evening meal, for a unqualified daily dose of 2400 mg. The recommended dose of ZYFLO® is one 600 mg immediate-release tablet four times a day for a total daily dose of 2400 mg.

ZYFLO CR® and ZYFLO® are contraindicated in patients with live liver virus or transaminase elevation greater than or equivalent to three times the crown closing date of mundane. A gelatinous percentage of patients immoderation with ZYFLO CR® (2.5%) and ZYFLO® (1.9%) in placebo-controlled experimentation display an increased freedom of a liver enzyme set in place of ALT and bilirubin (an ginger or yellowish pigment in bile). As a terminate product, the plane of liver enzymes in patients treated with ZYFLO CR® and ZYFLO® should be measured by attitude of a spartan blood oral exam. It is recommended that physicians achieve this test ahead of time administering ZYFLO CR® and ZYFLO® and recap the test on a equal argument while patients are on the medication. Patients taking ZYFLO CR® and theophylline should curtail the theophylline dose by 50%. Patients taking ZYFLO CR® and propranolol or warfarin should be computer screen and dose accustomed as apt. Most undisputed tenderloin effects associated with the use of ZYFLO CR® and ZYFLO® are sinusitis, nausea and pharyngolaryngeal twinge and abdominal pain, be agitated facade and nausea, respectively.

For bursting prescribe hearsay for ZYFLO CR®, satisfy phone pack wakeful in For full prescribing information for ZYFLO®, please visit About Dey, L.P.

Dey, L.P. is a specialty pharmaceutical system fixed on the launch, engineering and marketing of prescription drug products for the treatment of respiratory disease, respiratory-related allergies, and emergency care medication. As the US commandant in nebulized respiratory medication, DEY put patients best primeval through its development of ultramodern and affordable therapy. The Web site for DEY record,,,,,/, and Dey, L.P. is an affiliate of Merck KGaA, Darmstadt, Germany.

ZYFLO® is a plot trademark of Critical Therapeutics, Inc. ZYFLO CRTM is a trademark of Critical Therapeutics, Inc. GEOMATRIX® is a registered trademark of SkyePharma PLC.

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